Abstract
The superantigenic streptococcal erythrogenic toxins A and C (ETA/SPEA and ETC/SPEC) elicit the production by human peripheral blood mononuclear cells of substantial amounts of Th1-derived cytokines (interleukin-2 [IL-2] and gamma interferon) as well as anti-inflammatory cytokines (IL-10 and IL-1 receptor antagonist). In contrast, very low levels of IL-4 and no alpha interferon were induced. The production of these cytokines after stimulation with Streptococcus pyogenes heat-killed bacteria and lipopolysaccharide from gram negative bacteria differed qualitatively and quantitatively from that elicited by the superantigens.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Bacterial Proteins*
-
Cytokines / biosynthesis*
-
Exotoxins / pharmacology*
-
Humans
-
Interferon-gamma / biosynthesis
-
Interleukin 1 Receptor Antagonist Protein
-
Interleukin-10 / biosynthesis
-
Interleukin-2 / biosynthesis
-
Interleukin-4 / biosynthesis
-
Membrane Proteins*
-
Sialoglycoproteins / biosynthesis
-
Streptococcus pyogenes / immunology*
-
Superantigens / pharmacology*
Substances
-
Bacterial Proteins
-
Cytokines
-
Exotoxins
-
IL1RN protein, human
-
Interleukin 1 Receptor Antagonist Protein
-
Interleukin-2
-
Membrane Proteins
-
Sialoglycoproteins
-
SpeA protein, Streptococcus pyogenes
-
Superantigens
-
erythrogenic toxin
-
Interleukin-10
-
Interleukin-4
-
Interferon-gamma