Working memory in medicated patients with Parkinson's disease: the central executive seems to work

J Neurol Neurosurg Psychiatry. 1996 Mar;60(3):313-7. doi: 10.1136/jnnp.60.3.313.

Abstract

Objective: To determine whether a deficit of the central executive can explain the attentional deficits of patients with Parkinson's disease.

Methods: Fifteen patients with idiopathic Parkinson's disease and 15 controls were given a dual task paradigm minimising motor demands and combining verbal, visual, or spatial span with two conditions of articulatory suppression.

Results: Although the spans were systematically lower in medicated parkinsonian patients than in controls, suggesting a decrease of central processing resources, there was no direct evidence for a deficit of the central executive.

Conclusions: A deficit of the central executive either is not an inevitable feature of the disease, or is dependent on the nature of task (visuomotor v cognitive), or is corrected by dopaminergic medication.

MeSH terms

  • Aged
  • Attention / drug effects*
  • Case-Control Studies
  • Dopamine Agents / pharmacology
  • Female
  • Humans
  • Male
  • Memory Disorders / etiology
  • Memory Disorders / physiopathology
  • Memory Disorders / psychology*
  • Mental Processes / drug effects
  • Neuropsychological Tests
  • Parkinson Disease / complications
  • Parkinson Disease / drug therapy
  • Parkinson Disease / physiopathology
  • Parkinson Disease / psychology*
  • Psychomotor Performance / drug effects

Substances

  • Dopamine Agents