Plasmacytoid CD8 lymphoma: morphologic and immunologic characterization

Acta Haematol. 1995;94(4):204-9. doi: 10.1159/000204011.

Abstract

This study describes a 79 year-old female suffering from fever and lymphadenopathy. A lymph node biopsy showed diffuse infiltration of medium-sized cells with plasmacytoid features. The immunologic phenotype determined by cytometric analysis and immunochemistry showed suppressor T antigen (CD2, CD3, CD7, CD8) expression. Absence of CD5 expression characterized this abnormal T cell proliferation. Gamma T cell receptor rearrangement without immunoglobulin heavy-chain gene rearrangement confirmed the T lineage of these plasmacytoid cells and their clonality. Immunological studies are necessary for identification of this T lymphoma with B microscopic findings.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Base Sequence
  • CD8-Positive T-Lymphocytes*
  • DNA, Neoplasm / chemistry
  • Female
  • Flow Cytometry
  • Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
  • Humans
  • Immunophenotyping
  • Lymph Nodes / pathology
  • Lymphoma, T-Cell / genetics
  • Lymphoma, T-Cell / immunology*
  • Lymphoma, T-Cell / pathology*
  • Molecular Sequence Data
  • Polymerase Chain Reaction

Substances

  • DNA, Neoplasm