Near-hexaploid Ph-positive acute myeloid leukemia with major-BCR/ABL transcript

H Iwama; K Ohyashiki; J H Ohyashiki; T Shimamoto; T Fujimura; K Kawakubo; Y Kuriyama; A Kodama; K Toyama

doi:10.1016/0165-4608(95)00178-6

Near-hexaploid Ph-positive acute myeloid leukemia with major-BCR/ABL transcript

Cancer Genet Cytogenet. 1996 Jan;86(1):61-4. doi: 10.1016/0165-4608(95)00178-6.

Authors

H Iwama¹, K Ohyashiki, J H Ohyashiki, T Shimamoto, T Fujimura, K Kawakubo, Y Kuriyama, A Kodama, K Toyama

Affiliation

¹ First Department of Internal Medicine, Tokyo Medical College, Japan.

PMID: 8616789
DOI: 10.1016/0165-4608(95)00178-6

Abstract

We describe the first case of acute myeloid leukemia (AML) with a Philadelphia (Ph) translocation and a near-hexaploid range chromosome number, whose leukemic cells had the major-BCR/ABL transcript. The genesis of near-hexaploid leukemic cells might be due to endoreduplication of triploid leukemic cells with the Ph, since the relapsed leukemic cells had triploid range chromosomes with double Ph chromosomes.

Publication types

Case Reports

MeSH terms

Aneuploidy*
Base Sequence
Blotting, Southern
Female
Fusion Proteins, bcr-abl / genetics*
Humans
Karyotyping
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / diagnosis
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology
Leukemia, Myeloid, Acute / diagnosis
Leukemia, Myeloid, Acute / genetics*
Leukemia, Myeloid, Acute / pathology
Middle Aged
Molecular Sequence Data
RNA, Messenger / analysis

Substances

RNA, Messenger
Fusion Proteins, bcr-abl