High frequency of celiac disease in Down syndrome

E K George; M L Mearin; J Bouquet; B M von Blomberg; S O Stapel; R M van Elburg; E A de Graaf

doi:10.1016/s0022-3476(96)70369-4

High frequency of celiac disease in Down syndrome

J Pediatr. 1996 Apr;128(4):555-7. doi: 10.1016/s0022-3476(96)70369-4.

Authors

E K George¹, M L Mearin, J Bouquet, B M von Blomberg, S O Stapel, R M van Elburg, E A de Graaf

Affiliation

¹ Department of Pediatrics, University Hospital Leiden, The Netherlands.

PMID: 8618192
DOI: 10.1016/s0022-3476(96)70369-4

Abstract

We screened 115 children with Down syndrome for celiac disease, using antigliadin, antiendomysium, and antireticulin serum antibodies and an intestinal permeability test. Celiac disease was diagnosed in eight children, giving a frequency of 7.0%. We recommend screening for celiac disease in all persons with Down syndrome, with the use of at least the antiendomysium antibody determination.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Autoantibodies / analysis
Biomarkers / analysis
Celiac Disease / complications*
Celiac Disease / diagnosis
Celiac Disease / immunology
Child
Child, Preschool
Down Syndrome / complications*
Female
Gliadin / immunology
Humans
Male
Netherlands
Reticulin / immunology

Substances

Autoantibodies
Biomarkers
Reticulin
Gliadin