Multiple periorbital cutaneous myxomas progressing to scleromyxedema

J Am Acad Dermatol. 1996 May;34(5 Pt 2):928-30. doi: 10.1016/s0190-9622(96)90082-1.

Abstract

Myxomas are rare cutaneous tumors that have been associated with a variety of other abnormalities including atrial myxomas, endocrine abnormalities, and bone malformations. We describe a 38-year-old white man with multiple periorbital myxomas in whom myalgias, fatigue, and more diffuse cutaneous involvement developed. These findings were consistent with scleromyxedema. He also had an associated left subclavian deep venous thrombosis. The patient responded well to therapy with cyclophosphamide.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Agents, Alkylating / therapeutic use
  • Cyclophosphamide / therapeutic use
  • Facial Neoplasms / complications*
  • Facial Neoplasms / drug therapy
  • Facial Neoplasms / pathology
  • Fatigue / etiology
  • Humans
  • Male
  • Myxedema / etiology*
  • Myxoma / complications*
  • Myxoma / drug therapy
  • Myxoma / pathology
  • Orbit
  • Scleroderma, Localized / etiology
  • Skin Neoplasms / complications*
  • Skin Neoplasms / drug therapy
  • Skin Neoplasms / pathology
  • Thrombophlebitis / etiology

Substances

  • Antineoplastic Agents, Alkylating
  • Cyclophosphamide