Perioperative treatment with phosphatidic acid inhibitor (Lisofylline leads to prolonged survival of hearts in the guinea pig to rat xenotransplant model

Transplant Proc. 1996 Apr;28(2):738-9.

Authors

L A Valdivia¹, N Murase, A S Rao, G Rice, J W Singer, H Sun, S Todo, F Pan, V Subbotin, J J Fung, T E Starzl

Affiliation

¹ Pittsburgh Transplantation Institute, University of Pittsburgh Medical Center, Pennsylvania 15213, USA.

PMID: 8623374
PMCID: PMC2975523

No abstract available

Publication types

Comparative Study
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Adjuvants, Immunologic / administration & dosage
Adjuvants, Immunologic / therapeutic use*
Animals
Antibodies, Heterophile / analysis
Complement C3 / analysis
Graft Survival / drug effects*
Graft Survival / immunology
Guinea Pigs
Heart Transplantation / immunology*
Immunoglobulin G / analysis
Immunoglobulin M / analysis
Immunosuppressive Agents / therapeutic use
Intraoperative Period
Methylprednisolone / therapeutic use
Pentoxifylline / administration & dosage
Pentoxifylline / analogs & derivatives*
Pentoxifylline / therapeutic use
Phosphatidic Acids / antagonists & inhibitors
Rats
Rats, Inbred Lew
Transplantation, Heterologous / immunology*

Substances

Adjuvants, Immunologic
Antibodies, Heterophile
Complement C3
Immunoglobulin G
Immunoglobulin M
Immunosuppressive Agents
Phosphatidic Acids
lisofylline
Pentoxifylline
Methylprednisolone

Grants and funding