2(S)-((3,5-bis(trifluoromethyl)benzyl)-oxy)-3(S)-phenyl-4- ((3-oxo-1,2,4-triazol-5-yl)methyl)morpholine (1): a potent, orally active, morpholine-based human neurokinin-1 receptor antagonist

J Med Chem. 1996 Apr 26;39(9):1760-2. doi: 10.1021/jm950654w.

Authors

J J Hale¹, S G Mills, M MacCoss, S K Shah, H Qi, D J Mathre, M A Cascieri, S Sadowski, C D Strader, D E MacIntyre, J M Metzger

Affiliation

¹ Merck Research Laboratories, Rahway, New Jersey 07065, USA.

PMID: 8627597
DOI: 10.1021/jm950654w

No abstract available

MeSH terms

Administration, Oral
Animals
CHO Cells
Cricetinae
Humans
Morpholines / administration & dosage
Morpholines / chemistry
Morpholines / pharmacology*
Neurokinin-1 Receptor Antagonists*

Substances

L 742694
Morpholines
Neurokinin-1 Receptor Antagonists