Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci

I Heinze-Krauss; P Angehrn; P Guerry; P Hebeisen; C Hubschwerlen; I Kompis; M G Page; H G Richter; V Runtz; H Stalder; U Weiss; C C Wei

doi:10.1021/jm950886v

Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci

J Med Chem. 1996 Apr 26;39(9):1864-71. doi: 10.1021/jm950886v.

Authors

I Heinze-Krauss¹, P Angehrn, P Guerry, P Hebeisen, C Hubschwerlen, I Kompis, M G Page, H G Richter, V Runtz, H Stalder, U Weiss, C C Wei

Affiliation

¹ F. Hoffmann-La Roche Ltd., Basel, Switzerland.

PMID: 8627610
DOI: 10.1021/jm950886v

Abstract

The synthesis and structure-activity relationships of a new class of vinylcephalosporins substituted with a lactamyl residue are described. These compounds show excellent activity against enterococci and retain the broad spectrum activity of third-generation cephalosporins such as ceftriaxone.

MeSH terms

Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Cephalosporins / chemical synthesis*
Cephalosporins / chemistry
Cephalosporins / pharmacology*
Enterococcus / drug effects*
Microbial Sensitivity Tests
Spectrum Analysis
Staphylococcus / drug effects*
Streptococcus pneumoniae / drug effects*
Structure-Activity Relationship

Substances

Anti-Bacterial Agents
Cephalosporins