Translocation (9;11;22)(p22;q23;q11). A new type of complex variant translocation of t(9;11)(p22;q23) with MLL rearrangement

N Takahashi; I Miura; A Ohshima; T Nimura; K Hashimoto; Y Hatano; S Utsumi; M Kume; K Saito; Y Kobayashi; M Saito; M Seto; R Ueda; A B Miura

doi:10.1016/0165-4608(95)00297-9

Translocation (9;11;22)(p22;q23;q11). A new type of complex variant translocation of t(9;11)(p22;q23) with MLL rearrangement

Cancer Genet Cytogenet. 1996 May;88(1):26-9. doi: 10.1016/0165-4608(95)00297-9.

Authors

N Takahashi¹, I Miura, A Ohshima, T Nimura, K Hashimoto, Y Hatano, S Utsumi, M Kume, K Saito, Y Kobayashi, M Saito, M Seto, R Ueda, A B Miura

Affiliation

¹ Third Department of Internal Medicine, Akita University School of Medicine, Japan.

PMID: 8630974
DOI: 10.1016/0165-4608(95)00297-9

Abstract

We describe a patient with acute monocytic leukemia (M5a, FAB classification) associated with a new type of variant translocation (9;11). Southern blot analysis showed the rearrangement of the MLL (ALL-1/HRX) gene at 11q23. Fluorescence in situ hybridization (FISH) with painting probes of chromosomes 9, 11, and 22 revealed the translocation as t(9;11;22) (p22;q23;q11). This is more evidence that the production of chimeric mRNA following the translocation of the LTG9 (MLLT3/AF9) gene at 9p22 to 11q is a critical event in this leukemia subtype.

Publication types

Case Reports

MeSH terms

Adult
Blotting, Southern
Chromosomes, Human, Pair 11*
Chromosomes, Human, Pair 22*
Chromosomes, Human, Pair 9*
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Leukemia, Monocytic, Acute / genetics*
Male
Translocation, Genetic*