(2S,4S)-2-amino-4-(4,4-diphenylbut-1-yl)- pentane-1,5-dioic acid: a potent and selective antagonist for metabotropic glutamate receptors negatively linked to adenylate cyclase

J Med Chem. 1996 Feb 16;39(4):814-6. doi: 10.1021/jm9508144.

Authors

C G Wermuth¹, A Mann, A Schoenfelder, R A Wright, B G Johnson, J P Burnett, N G Mayne, D D Schoepp

Affiliation

¹ Centre de Neurochimie du CNRS, Strasbourg, France.

PMID: 8632404
DOI: 10.1021/jm9508144

No abstract available

MeSH terms

Adenylyl Cyclases / metabolism*
Amino Acids, Dicarboxylic / chemical synthesis*
Amino Acids, Dicarboxylic / pharmacology*
Animals
Binding, Competitive
Brain / metabolism
Cell Line
Cell Membrane / metabolism
Cycloleucine / analogs & derivatives
Cycloleucine / pharmacology
Glutamic Acid / metabolism
Humans
Indicators and Reagents
Inositol Phosphates / metabolism
Kinetics
Neurotoxins / pharmacology
Phosphatidylinositols / metabolism
Rats
Receptors, Metabotropic Glutamate / antagonists & inhibitors*

Substances

2-amino-4-(4,4-diphenylbut-1-yl)-pentane-1,5-dioic acid
Amino Acids, Dicarboxylic
Indicators and Reagents
Inositol Phosphates
Neurotoxins
Phosphatidylinositols
Receptors, Metabotropic Glutamate
Cycloleucine
1-amino-1,3-dicarboxycyclopentane
Glutamic Acid
Adenylyl Cyclases