Isolation, characterization, and mapping to human chromosome 11q24-25 of a cDNA encoding a highly conserved putative transmembrane protein, TMC

Biochim Biophys Acta. 1996 May 2;1306(2-3):137-41. doi: 10.1016/0167-4781(96)00025-5.

Abstract

We report the isolation of a novel human cDNA encoding a putative transmembrane protein, TMC. The predicted protein sequence is highly conserved evolutionarily. The cDNA clone was mapped to human chromosome 11q24-25 by fluorescence in situ hybridization. mRNA expression was observed in all tissues tested with the highest levels in testes and ovary.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human, Pair 11*
  • Conserved Sequence
  • DNA, Complementary
  • Hexosyltransferases
  • Humans
  • In Situ Hybridization, Fluorescence
  • Membrane Proteins / genetics*
  • Molecular Sequence Data
  • Sequence Homology, Amino Acid

Substances

  • DNA, Complementary
  • Membrane Proteins
  • Hexosyltransferases
  • STT3A protein, human

Associated data

  • GENBANK/D28952
  • GENBANK/L34260
  • GENBANK/L38961
  • GENBANK/P39007
  • GENBANK/U13019