Abstract
Selected human T cell clones reactive with group 5 allergens of timothy grass (Phl p 5) were cross-stimulated in specific proliferation assays with group 1 allergens of rye grass (Lol p 1). Such interspecies cross-reactivities result obviously from structural motifs presented on defined Phl p 5 fragments as shown with recombinant Phl p 5 products.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Allergens / genetics
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Allergens / immunology*
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Amino Acid Sequence
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Antigens, Plant
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Cross Reactions
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Epitopes, T-Lymphocyte / genetics
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Epitopes, T-Lymphocyte / immunology*
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Humans
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In Vitro Techniques
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Lolium / genetics
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Lolium / immunology*
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Lymphocyte Activation
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Molecular Sequence Data
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Plant Proteins / genetics
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Plant Proteins / immunology
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Poaceae / genetics
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Poaceae / immunology*
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Pollen / genetics
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Pollen / immunology
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Rhinitis, Allergic, Seasonal / immunology
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Sequence Homology, Amino Acid
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Species Specificity
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T-Lymphocytes / immunology
Substances
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Allergens
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Antigens, Plant
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Epitopes, T-Lymphocyte
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Lol p I protein, Lolium perenne
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Phl p V protein, Phleum pratense
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Plant Proteins