Identification of the telomeres on Schistosoma mansoni chromosomes by FISH

J Parasitol. 1996 Jun;82(3):511-2.

Abstract

The telomeres (molecular termini) of chromosomes play an important role in maintaining the structural integrity of the chromosome. Using a deoxyoligomer that contains the core sequence TTAGGG, we identified by fluorescence in situ hybridization (FISH) the telomeres on all 8 pairs of Schistosoma mansoni mitotic metaphase chromosomes. Our results indicate that S. mansoni exhibits a telomere sequence typical of other species.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • DNA Probes / chemistry
  • In Situ Hybridization, Fluorescence*
  • Molecular Sequence Data
  • Repetitive Sequences, Nucleic Acid
  • Schistosoma mansoni / genetics*
  • Schistosoma mansoni / ultrastructure
  • Telomere / genetics*

Substances

  • DNA Probes