The cerebellum: a neuronal learning machine?

Science. 1996 May 24;272(5265):1126-31. doi: 10.1126/science.272.5265.1126.

Abstract

Comparison of two seemingly quite different behaviors yields a surprisingly consistent picture of the role of the cerebellum in motor learning. Behavioral and physiological data about classical conditioning of the eyelid response and motor learning in the vestibulo-ocular reflex suggests that (i) plasticity is distributed between the cerebellar cortex and the deep cerebellar nuclei; (ii) the cerebellar cortex plays a special role in learning the timing of movement; and (iii) the cerebellar cortex guides learning in the deep nuclei, which may allow learning to be transferred from the cortex to the deep nuclei. Because many of the similarities in the data from the two systems typify general features of cerebellar organization, the cerebellar mechanisms of learning in these two systems may represent principles that apply to many motor systems.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Blinking / physiology
  • Cerebellar Cortex / anatomy & histology
  • Cerebellar Cortex / physiology
  • Cerebellar Nuclei / anatomy & histology
  • Cerebellar Nuclei / physiology
  • Cerebellum / anatomy & histology
  • Cerebellum / physiology*
  • Conditioning, Classical / physiology
  • Eye Movements / physiology
  • Eyelids / physiology
  • Humans
  • Learning / physiology*
  • Neural Pathways
  • Neuronal Plasticity
  • Psychomotor Performance
  • Reflex, Vestibulo-Ocular / physiology