Abstract
Purpose:
To examine and treat a patient with acquired immunodeficiency syndrome (AIDS) who had mildly hyperemic conjunctiva and epithelial keratopathy in both eyes.
Methods:
The patient underwent conjunctival biopsy. The specimen was examined by transmission electron microscopy.
Results:
Septata intestinalis was demonstrated to be the cause of keratoconjunctivitis in the patient. The keratoconjunctivitis resolved after three weeks of therapy with topical fumagillin. No organisms were seen on repeat conjunctival biopsy.
Conclusions:
Microsporidial keratoconjunctivitis in patients with AIDS can be caused by S. intestinalis. This condition appears to respond to topical fumagillin.
MeSH terms
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AIDS-Related Opportunistic Infections / drug therapy
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AIDS-Related Opportunistic Infections / etiology*
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AIDS-Related Opportunistic Infections / parasitology
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Administration, Topical
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Adult
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Animals
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Antiprotozoal Agents / therapeutic use
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Biopsy
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Conjunctiva / parasitology
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Conjunctiva / pathology
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Cyclohexanes
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Epithelium / parasitology
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Epithelium / pathology
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Eye Infections, Parasitic / drug therapy
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Eye Infections, Parasitic / etiology*
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Eye Infections, Parasitic / parasitology
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Fatty Acids, Unsaturated / therapeutic use
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Feces / parasitology
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Humans
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Intestinal Diseases, Parasitic / drug therapy
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Intestinal Diseases, Parasitic / etiology
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Keratoconjunctivitis / drug therapy
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Keratoconjunctivitis / parasitology*
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Male
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Microsporida / isolation & purification
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Microsporida / ultrastructure
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Microsporidiosis / drug therapy
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Microsporidiosis / etiology*
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Microsporidiosis / parasitology
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Ophthalmic Solutions
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Sesquiterpenes
Substances
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Antiprotozoal Agents
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Cyclohexanes
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Fatty Acids, Unsaturated
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Ophthalmic Solutions
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Sesquiterpenes
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fumagillin