Cloning of the cDNA encoding the mouse ATBF1 transcription factor

Gene. 1996 Feb 12;168(2):227-31. doi: 10.1016/0378-1119(95)00740-7.

Abstract

We have isolated a mouse ATBF1 cDNA which is 12-kb long and capable of encoding a 406-kDa protein containing four homeodomains and 23 zinc-finger motifs. Mouse ATBF1 is 94% homologous to the human ATBF1-A transcription factor. Northern blot and RNase protection analysis showed that levels of ATBF1 transcripts were low in adult mouse tissues, but high in developing brain, consistent with a role for ATBF1 in neuronal differentiation.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Blotting, Northern
  • Cell Line
  • Cloning, Molecular
  • DNA, Complementary
  • DNA-Binding Proteins / biosynthesis*
  • DNA-Binding Proteins / genetics*
  • Genes, Homeobox
  • Homeodomain Proteins*
  • Humans
  • Mice / genetics*
  • Molecular Sequence Data
  • Molecular Weight
  • Organ Specificity
  • RNA, Messenger / analysis
  • RNA, Messenger / biosynthesis
  • Rats
  • Restriction Mapping
  • Sequence Homology, Amino Acid
  • Transcription Factors / biosynthesis
  • Transcription Factors / genetics
  • Transcription, Genetic
  • Zinc Fingers

Substances

  • DNA, Complementary
  • DNA-Binding Proteins
  • Homeodomain Proteins
  • RNA, Messenger
  • Transcription Factors
  • Zfhx3 protein, mouse
  • Zfhx3 protein, rat
  • ZFHX3 protein, human

Associated data

  • GENBANK/D26046