Abstract
Hepatitis C virus (HCV) genotype 1 isolates from 31 patients on dialysis or with renal transplants were studied for evidence of patient-to-patient spread of infection. Nucleotide sequences from a variable region (NSSV) of the NSSa (nonstructural 5a) gene and the hypervariable region of the second envelope gene. (env2) were compared. Investigation of phylogenetically related isolates of HCV type 1a with identical derived amino acid sequences in the NS5V led to recognition of a cluster of 4 patients who had received renal transplants within an 8-day period in 1984. This demonstrates the value of molecular epidemiologic techniques in reconstructing routes of infection and adds to the evidence for nosocomial transmission of HCV by routes other than blood transfusion.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Base Sequence
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Cross Infection / etiology*
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Cross Infection / genetics*
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Hepatitis C / etiology*
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Hepatitis C / genetics*
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Humans
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Kidney Transplantation / adverse effects*
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Molecular Sequence Data
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Urology Department, Hospital
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Viral Nonstructural Proteins / genetics*
Substances
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Viral Nonstructural Proteins
Associated data
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GENBANK/U56486
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GENBANK/U56487
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GENBANK/U56488
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GENBANK/U56489
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GENBANK/U56490
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GENBANK/U56491
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GENBANK/U56492
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GENBANK/U56493
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GENBANK/U56494
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GENBANK/U56495
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GENBANK/U56496
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GENBANK/U56497
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GENBANK/U56498
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GENBANK/U56499
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GENBANK/U56500
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GENBANK/U56501
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GENBANK/U56502
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GENBANK/U56503
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GENBANK/U56504
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GENBANK/U56505
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GENBANK/U56506
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GENBANK/U56507
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GENBANK/U56508
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GENBANK/U56509
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GENBANK/U56510
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GENBANK/U56511
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GENBANK/U56512
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GENBANK/U56513
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GENBANK/U56514
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GENBANK/U56515