Abstract
A human gene encoding a putative RNA helicase, designated DDX10, was identified 400 kb telomeric to the ataxia-telangiectasia gene at chromosome 11q22-q23. The predicted amino acid sequence shows very high similarity to a subgroup of DEAD-box RNA helicases involved in ribosome biogenesis. This novel gene encodes a 3.2-kb transcript in a variety of human tissues. A processed pseudogene of DDX10 was detected at chromosome 9q21-q22. We observed a rare trinucleotide repeat length polymorphism within the coding sequence of DDX10.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Ataxia Telangiectasia / genetics
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Base Sequence
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Cell Line
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Chromosomes, Human, Pair 11*
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Chromosomes, Human, Pair 9
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Cricetinae
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DNA, Complementary
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Gene Expression
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Humans
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Molecular Sequence Data
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Pseudogenes
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RNA Helicases
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RNA Nucleotidyltransferases / genetics*
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Sequence Homology, Amino Acid
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Trinucleotide Repeats
Substances
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DNA, Complementary
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RNA Nucleotidyltransferases
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RNA Helicases