Abstract
The POU transcription factor Oct-6, also known as SCIP or Tst-1, has been implicated as a major transcriptional regulator in Schwann cell differentiation. Microscopic and immunochemical analysis of sciatic nerves of Oct-6(-/-) mice at different stages of postnatal development reveals a delay in Schwann cell differentiation, with a transient arrest at the promyelination stage. Thus, Oct-6 appears to be required for the transition of promyelin cells to myelinating cells. Once these cells progress past this point, Oct-6 is no longer required, and myelination occurs normally.
MeSH terms
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Animals
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Animals, Newborn
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Axons / ultrastructure
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Base Sequence
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Cell Differentiation
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Gene Expression
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Mice
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Mice, Inbred C57BL
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Molecular Sequence Data
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Myelin P0 Protein / genetics
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Myelin P0 Protein / metabolism
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Myelin Proteins / genetics
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Myelin Proteins / metabolism
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Myelin Sheath / physiology
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Octamer Transcription Factor-6
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Recombination, Genetic
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Schwann Cells / cytology*
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Schwann Cells / physiology
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Sciatic Nerve / cytology
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Sciatic Nerve / growth & development
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Stem Cells
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Transcription Factors / genetics*
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Transcription Factors / physiology*
Substances
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Myelin P0 Protein
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Myelin Proteins
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Pou3f1 protein, mouse
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Transcription Factors
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Octamer Transcription Factor-6