Abstract
The presence of molecular alterations in the c-K-ras and p53 genes in a small bowel adenocarcinoma arising in a case of Peutz-Jeghers syndrome is reported. The absence of mutations at codon 12 and 13 of the c-K-ras gene in the hamartoma and carcinoma indicates that this oncogene does not contribute to its development. On the other hand, p53 protein overexpression was detected in a small proportion (5-10%) of adenocarcinoma cells. Our findings suggest that p53 inactivation occur in late stages of tumour progression.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Adenocarcinoma / complications
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Adenocarcinoma / genetics*
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Adenocarcinoma / pathology
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Base Sequence
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Codon / genetics
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Genes, p53* / genetics
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Genes, ras* / genetics
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Humans
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Ileal Neoplasms / complications
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Ileal Neoplasms / genetics*
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Ileal Neoplasms / pathology
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Jejunal Neoplasms / complications
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Jejunal Neoplasms / genetics*
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Jejunal Neoplasms / pathology
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Male
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Middle Aged
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Molecular Sequence Data
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Mutation
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Peutz-Jeghers Syndrome / complications*
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Peutz-Jeghers Syndrome / pathology
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Polymerase Chain Reaction