Growth rate of lung metastases and S-phase fraction as determined by flow cytometry from the primary tumour in 25 patients with bone or soft-tissue sarcomas

C Blomqvist; R Huuhtanen; Y Pan; T Wiklund; M Tarkkanen; M Virolainen; B Tribukait

doi:10.1038/bjc.1996.293

Growth rate of lung metastases and S-phase fraction as determined by flow cytometry from the primary tumour in 25 patients with bone or soft-tissue sarcomas

Br J Cancer. 1996 Jun;73(12):1556-9. doi: 10.1038/bjc.1996.293.

Authors

C Blomqvist¹, R Huuhtanen, Y Pan, T Wiklund, M Tarkkanen, M Virolainen, B Tribukait

Affiliation

¹ Department of Radiotherapy and Oncology, University of Helsinki, Finland.

Abstract

A significant correlation (r = -0.48) was found between the logarithm of the S-phase fraction of the primary tumour (SPF) and the logarithm of the doubling time of lung metastases (T2). The estimated median cell loss factor was 88% (range 35-99%).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Bone Neoplasms / pathology*
Cell Division / physiology
Female
Flow Cytometry
Humans
Lung Neoplasms / pathology*
Lung Neoplasms / secondary*
Male
Middle Aged
Regression Analysis
S Phase / physiology*
Sarcoma / pathology*
Soft Tissue Neoplasms / pathology*