Abstract
A total of 26 patients with advanced colorectal cancer received 60 mg/m2 methotrexate i.v. on days 1-4; 400 mg/m2 5-fluorouracil i.v. on days 2, 3, 5, and 6; and 100 mg/m2 6S-leucovorin i.v. on days 2, 3, 5, and 6. Interferon-alpha 2b at a dose of 3 million U was given i.m. daily for the 6 days of chemotherapy. Courses were repeated every 3 weeks. There were four partial responses for a response rate of 15% (95% confidence interval 2-28%): In all, 14 patients expressed grade 3 toxicity; 9 patients had diarrhea, 3 had stomatitis, and 2 developed leukopenia. In conclusion, multimodal biochemical modulation of 5-fluorouracil, at least on this schedule, does not seem to be effective, as it results in severe toxicity.
MeSH terms
-
Adult
-
Aged
-
Antineoplastic Combined Chemotherapy Protocols / adverse effects
-
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
-
Colorectal Neoplasms / drug therapy*
-
Drug Administration Schedule
-
Feasibility Studies
-
Female
-
Fluorouracil / administration & dosage
-
Fluorouracil / adverse effects
-
Humans
-
Interferon alpha-2
-
Interferon-alpha / administration & dosage
-
Interferon-alpha / adverse effects
-
Leucovorin / administration & dosage
-
Leucovorin / adverse effects
-
Male
-
Methotrexate / administration & dosage
-
Methotrexate / adverse effects
-
Middle Aged
-
Pilot Projects
-
Recombinant Proteins
-
Remission Induction
Substances
-
Interferon alpha-2
-
Interferon-alpha
-
Recombinant Proteins
-
Leucovorin
-
Fluorouracil
-
Methotrexate