Abstract
Here, we show that the African swine fever virus 5-HL gene is a highly conserved viral gene and contains all known protein domains associated with Bcl-2 activity, including those involved with dimerization, mediating cell death, and protein-binding functions, and that its protein product, p21, suppresses apoptotic cell death in the mammalian lymphoid cell line FL5.12. Thus, 5-HL is a true functional viral member of the Bcl-2 gene family.
MeSH terms
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African Swine Fever Virus / genetics
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African Swine Fever Virus / physiology*
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Amino Acid Sequence
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Animals
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Apoptosis*
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Base Sequence
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Cell Line
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Cell Line, Transformed
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Humans
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Interleukin-3 / metabolism
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Mice
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Molecular Sequence Data
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Proto-Oncogene Proteins / chemistry*
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Proto-Oncogene Proteins c-bcl-2
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Sequence Homology, Amino Acid
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Viral Proteins / chemistry
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Viral Proteins / genetics
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Viral Proteins / physiology*
Substances
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5-HL protein, African swine fever virus
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Interleukin-3
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-bcl-2
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Viral Proteins
Associated data
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GENBANK/L08246
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GENBANK/L16462
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GENBANK/L22473
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GENBANK/L26545
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GENBANK/Q07440
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GENBANK/U16811
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GENBANK/X59988
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GENBANK/Z23116