Abstract
In this study, we show that HPV-16 E5 induced anchorage-independent growth in immortalized human epidermal keratinocytes and that HPV-16 E5 in human keratinocytes had higher expression of c-jun and junB; also, we investigated the role of transcriptional initiation pathways in the expression elevation. In addition, Ras-dependent pathway, as well as PKC-dependent pathway, leads to HPV-16 E5-induced c-jun gene expression.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
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Cell Division
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Cells, Cultured
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Gene Expression Regulation*
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Genes, jun*
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Humans
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Isoquinolines / pharmacology
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Keratinocytes / metabolism
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Oncogene Proteins, Viral / physiology*
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Piperazines / pharmacology
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Simian virus 40
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Sulfonamides*
Substances
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Isoquinolines
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Oncogene Proteins, Viral
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Piperazines
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Sulfonamides
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oncogene protein E5, Human papillomavirus type 16
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1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
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N-(2-guanidinoethyl)-5-isoquinolinesulfonamide