[Prevention of second primary cancer with vitamin supplementation in patients treated for head and neck cancers]

I Bairati; F Brochet; J Roy; M Gélinas; A Nabid; B Têtu; B Mâsse; F Meyer

[Prevention of second primary cancer with vitamin supplementation in patients treated for head and neck cancers]

Bull Cancer Radiother. 1996;83(1):12-6.

[Article in French]

Authors

I Bairati¹, F Brochet, J Roy, M Gélinas, A Nabid, B Têtu, B Mâsse, F Meyer

Affiliation

¹ Groupe de recherche en épidémiologie de l'Université Laval, Québec, Canada.

PMID: 8679274

Abstract

Second primary cancers often occur in head and neck cancer patients successfully treated by radiation therapy. Experimental and epidemiological data suggest that these second primaries might be prevented by antioxidant vitamins, in particular beta-carotene and alpha-tocopherol. A randomized double-blind clinical trial is being conducted in Canada to determine whether vitamin supplementation with beta-carotene (30 mg/d) and alpha-tocopherol (400 IU/d) reduces the incidence of second primaries in head and neck cancer patients treated by radiation therapy.

Publication types

English Abstract
Review

MeSH terms

Acetylcysteine / administration & dosage
Antineoplastic Agents / therapeutic use*
Antioxidants / therapeutic use
Carcinoma, Squamous Cell / diet therapy*
Carcinoma, Squamous Cell / pathology
Carotenoids / administration & dosage
Follow-Up Studies
Head and Neck Neoplasms / diet therapy*
Head and Neck Neoplasms / pathology
Humans
Neoplasm Staging
Neoplasms, Second Primary / prevention & control*
Risk Factors
Vegetables
Vitamin A / administration & dosage
Vitamin E / administration & dosage
Vitamins / therapeutic use*
beta Carotene

Substances

Antineoplastic Agents
Antioxidants
Vitamins
beta Carotene
Vitamin A
Vitamin E
Carotenoids
Acetylcysteine