[Clinical, biological and developmental aspects of alcoholic ketoacidosis]

Presse Med. 1996 Jun 8;25(20):924-8.
[Article in French]

Abstract

Objectives: To review cases of alcoholic ketoacidosis in order to better ascertain therapeutic management.

Methods: The medical files of 32 alcoholic patients with ketoacidosis hospitalized in the Saint-Pierre general hospital of the Reunion island from January 1, 1991 through 31 August 1994 were analyzed.

Results: There were 18 women and 14 men, mean age 47 years. The first clinical signs were predominated by digestive (n = 22) or neurological disorders (n = 10). Acidosis was severe (mean pH = 7.12) and always associated with a wide anion gap (mean anion gap = 35). There were 3 types of glycemic status: hypoglycemia 10 cases, normal or subnormal glycemia in 19 cases (mean glycemia = 9.3 mmol/l) and hyperglycemia above 20 mmol/l in 3 cases. Hypophosphatemia, elevated serum lactate levels and cytolytic hepatitis were the main abnormalities associated.

Conclusion: Short-term outcome was favorable in all cases after rehydration. The use of insulin may be dangerous and needs to be avoided.

Publication types

  • English Abstract

MeSH terms

  • Acidosis / blood
  • Acidosis / etiology*
  • Acidosis / physiopathology
  • Adult
  • Aged
  • Alcoholism / blood
  • Alcoholism / complications*
  • Alcoholism / physiopathology
  • Female
  • Hospitalization
  • Humans
  • Ketosis / blood
  • Ketosis / etiology*
  • Ketosis / physiopathology
  • Male
  • Middle Aged
  • Prognosis
  • Recurrence
  • Retrospective Studies
  • Time Factors