Cytology of grade 1 papillary transitional cell carcinoma. A comparison of cytologic, architectural and morphometric criteria in cystoscopically obtained urine

Acta Cytol. 1996 Jul-Aug;40(4):676-82. doi: 10.1159/000333938.

Abstract

Objective: To assess the diagnostic criteria for grade 1 papillary transitional cell carcinoma (TCC) in cystoscopically obtained urine.

Study design: We compared the sensitivity, specificity and positive predictive value of cytologic, architectural and morphometric (primarily architectural) criteria in 177 specimens with corresponding biopsy follow-up.

Results: Sensitivities ranged from 22% to 44%, specificities from 69% to 85% and positive predictive values from 59% to 66%.

Conclusion: The currently described cytologic, architectural and morphometric criteria are inadequate for the identification of grade 1 papillary TCC, and the cytologic diagnosis of grade 1 papillary TCC in cystoscopically obtained urine remains unreliable.

Publication types

  • Comparative Study

MeSH terms

  • Biopsy
  • Carcinoma, Transitional Cell / pathology*
  • Carcinoma, Transitional Cell / urine*
  • Coloring Agents
  • Diagnosis, Differential
  • Female
  • Humans
  • Predictive Value of Tests
  • Sensitivity and Specificity
  • Urinary Bladder Neoplasms / pathology*
  • Urinary Bladder Neoplasms / urine*
  • Urine / cytology*

Substances

  • Coloring Agents