Abstract
In this study, we demonstrated that purified capsular polysaccharide of Cryptococcus neoformans is a potent inducer of interleukin-10 (IL-10) secretion by human monocytes. Endogenous IL-10 was involved in regulating tumor necrosis factor alpha and IL-1beta secretion by human monocytes in response to encapsulated C. neoformans strains. Our results suggest a new immunosuppressive effect exerted by glucuronoxylomannan through the induction of IL-10, a potent downregulator of proinflammatory cytokines.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Antibodies, Monoclonal / pharmacology
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Antigens, Bacterial / isolation & purification
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Cryptococcus neoformans / chemistry
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Cryptococcus neoformans / immunology*
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Down-Regulation
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Humans
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Immune Tolerance
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In Vitro Techniques
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Interleukin-1 / metabolism
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Interleukin-10 / metabolism*
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Monocytes / drug effects*
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Monocytes / immunology*
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Polymyxin B / pharmacology
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Polysaccharides / immunology
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Polysaccharides / isolation & purification
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Polysaccharides / pharmacology*
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Tumor Necrosis Factor-alpha / metabolism
Substances
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Anti-Bacterial Agents
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Antibodies, Monoclonal
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Antigens, Bacterial
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Interleukin-1
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Polysaccharides
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Tumor Necrosis Factor-alpha
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cryptococcal polysaccharide
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Interleukin-10
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glucuronoxylomannan
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Polymyxin B