Abstract
Twenty-seven patients who had a relapse of astrocytomas or supra-tentorial malignant gliomas, previously treated by radio-surgical combination or exclusive irradiation, underwent a combination of 3 courses of 5-FU, cis-platyl and hypofractionated irradiation. No objective response was observed, but there was a progression of the tumor in 33% of the cases, and no change in 67%. Overall median survival was 7 +/- 1.5 months. The 20 patients with grade III or IV astrocytomas had a lower median rate than the 7 patients with grade II astrocytomas or oligodendrogliomas: 6 +/- 1.8 months versus 18 +/- 3.2 (P = 0.16). Median survival was 14 +/- 2.7 months for neurological responders and 6 +/- 2.1 months for non-responders (P = 0.017).
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Adult
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Antimetabolites, Antineoplastic / therapeutic use*
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Astrocytoma / mortality
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Astrocytoma / radiotherapy
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Astrocytoma / therapy*
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Brain Neoplasms / mortality
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Brain Neoplasms / radiotherapy
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Brain Neoplasms / therapy*
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Cisplatin / therapeutic use*
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Data Interpretation, Statistical
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Female
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Fluorouracil / therapeutic use*
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Frontal Lobe
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Glioblastoma / mortality
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Glioblastoma / radiotherapy
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Glioblastoma / therapy*
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Humans
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Male
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Middle Aged
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Neoplasm Recurrence, Local / mortality
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Neoplasm Recurrence, Local / radiotherapy
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Neoplasm Recurrence, Local / therapy*
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Occipital Lobe
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Oligodendroglioma / mortality
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Oligodendroglioma / radiotherapy
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Oligodendroglioma / therapy*
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Parietal Lobe
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Radiotherapy Dosage
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Temporal Lobe
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Thalamus
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Time Factors
Substances
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Antimetabolites, Antineoplastic
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Cisplatin
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Fluorouracil