Abstract
G9315, a complex extracted from Glycyrrhizae inflata Bat (III), consists of 6 flavonoids with significant antioxidant effects. At 1 mg dose it inhibited the mouse ear edema induced by croton oil, and showed strong anti-promoting effects on two-stage carcinogenesis in mouse skin induced by DMBA plus croton oil. The TPA enhanced 32Pi-incorporation into phospholipid fraction in HeLa cells was inhibited, and the micronuclei in mouse bone marrow cells induced by cytoxan was also depressed.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anticarcinogenic Agents / isolation & purification
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Anticarcinogenic Agents / pharmacology*
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Antimutagenic Agents / isolation & purification
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Antimutagenic Agents / pharmacology*
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Croton Oil
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Ear Diseases / chemically induced
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Ear Diseases / pathology
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Edema / chemically induced
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Edema / pathology
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Female
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Flavonoids / isolation & purification
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Flavonoids / pharmacology*
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Glycyrrhiza / chemistry*
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Mice
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Micronucleus Tests
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Papilloma / chemically induced
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Papilloma / pathology*
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Plants, Medicinal*
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Skin Neoplasms / chemically induced
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Skin Neoplasms / pathology*
Substances
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Anticarcinogenic Agents
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Antimutagenic Agents
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Flavonoids
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G9315
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Croton Oil