Effects of oil adjuvant on systemic response to Escherichia coli lipopolysaccharide in swine

J Vet Med Sci. 1995 Dec;57(6):1089-91. doi: 10.1292/jvms.57.1089.

Abstract

Intramuscular injection of 0.1 mg/kg of Escherichia coli lipopolysaccharide (LPS) mixed with Freund's complete adjuvant (LPS+FCA) in piglets mitigated the leukopenia and TNF-alpha and cortisol levels in the serum compared with that of LPS suspended in LPS-free saline. The endotoxin level in the serum of the LPS+FCA was remarkably reduced. These results suggest that the addition of oil adjuvant mitigate the systemic toxicity of LPS.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Bacterial Vaccines*
  • Escherichia coli / immunology*
  • Escherichia coli Infections / immunology
  • Escherichia coli Infections / prevention & control*
  • Freund's Adjuvant
  • Hydrocortisone / blood
  • Injections, Intramuscular
  • Leukopenia / prevention & control*
  • Lipopolysaccharides / administration & dosage*
  • Lipopolysaccharides / immunology
  • Lipopolysaccharides / toxicity
  • Oils
  • Sodium Chloride
  • Swine
  • Tumor Necrosis Factor-alpha / biosynthesis

Substances

  • Bacterial Vaccines
  • Lipopolysaccharides
  • Oils
  • Tumor Necrosis Factor-alpha
  • Sodium Chloride
  • Freund's Adjuvant
  • Hydrocortisone