Abstract
Eighteen previously untreated patients with metastatic carcinoma of the prostate were treated with LHRH analogue. They were divided into 3 groups according to the degree of glandular differentiation. In all groups, a transient rise of PAP and PSA was observed after the LH and testosterone surge. However, relative values of LH, testosterone, PAP and PSA did not differ significantly among the 3 groups. These facts suggest that a transient rise of PAP and PSA is caused by testosterone surge independently from the degree of glandular differentiation after LHRH analogue administration in patients with advanced prostatic cancer.
MeSH terms
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Acid Phosphatase / blood*
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Aged
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Aged, 80 and over
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Antineoplastic Agents, Hormonal / therapeutic use*
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Humans
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Leuprolide / therapeutic use*
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Luteinizing Hormone / blood
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Male
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Middle Aged
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Neoplasm Metastasis
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Neoplasms, Hormone-Dependent / blood
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Neoplasms, Hormone-Dependent / drug therapy*
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Neoplasms, Hormone-Dependent / pathology
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Prognosis
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Prostate / enzymology*
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Prostate-Specific Antigen / blood*
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Prostatic Neoplasms / blood
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Prostatic Neoplasms / drug therapy*
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Prostatic Neoplasms / pathology
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Testosterone / blood
Substances
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Antineoplastic Agents, Hormonal
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Testosterone
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Luteinizing Hormone
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Acid Phosphatase
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Prostate-Specific Antigen
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Leuprolide