The molecular basis of somatic hypermutation of immunoglobulin genes

U Storb

doi:10.1016/s0952-7915(96)80059-8

The molecular basis of somatic hypermutation of immunoglobulin genes

Curr Opin Immunol. 1996 Apr;8(2):206-14. doi: 10.1016/s0952-7915(96)80059-8.

Author

U Storb¹

Affiliation

¹ Department of Molecular Genetics and Cell Biology, University of Chicago, IL 60637, USA. [email protected]

PMID: 8725944
DOI: 10.1016/s0952-7915(96)80059-8

Abstract

Somatic hypermutation amplifies the variable region repertoire of immunoglobulin genes. Recent experimental evidence has thrown light on various molecular models of somatic hypermutation. A link between somatic hypermutation and transcription coupled DNA repair is shaping up.

Publication types

Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Animals
Genes, Immunoglobulin / genetics*
Models, Genetic
Mutation / immunology*

Grants and funding

GM38649/GM/NIGMS NIH HHS/United States