Condylectomy and menisectomy were performed in left TMJ of 14 rabbits, of them, 7 were treated with periosteal interposition and 7 without. Sixteen weeks after operation, condylar cartilage of the right side were studied and compared with 7 normal rabbits by means of histology and histochemistry. The results show that an operation of high condylectomy and menisectomy with or without interposition on one side of TMJ will result in degenerative changes in the other side (non-operated side). The degenerative changes in the rabbits without any interposition are more serious than those with periosteal interposition.