Abstract
We studied the role of lipids in the pathogenesis of noninsulin-dependent diabetes mellitus (NIDDM) in Pima Indians. High plasma levels of nonesterified fatty acid (NEFA) predicted development of NIDDM, but this effect cannot entirely be explained by the glucose-fatty acid cycle. Dyslipidemia, although often associated with diabetes, did not seem to predict NIDDM and might rather be associated with, or the consequence of insulin resistance. In some individuals, a single amino acid substitution in the intestinal fatty acid binding protein could result in increased rates of intestinal absorption of dietary NEFA and thereby contribute to increased lipid-oxidation rates and insulin resistance.
MeSH terms
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Arizona
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Carrier Proteins / analysis
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Diabetes Mellitus, Type 2 / diagnosis
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Diabetes Mellitus, Type 2 / physiopathology*
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Fatty Acid-Binding Protein 7
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Fatty Acid-Binding Proteins
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Fatty Acids / analysis
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Fatty Acids, Nonesterified / metabolism
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Female
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Humans
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Indians, North American*
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Insulin Resistance
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Intestinal Mucosa / metabolism
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Lipids / physiology*
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Longitudinal Studies
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Male
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Myelin P2 Protein / analysis
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Neoplasm Proteins*
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Polymorphism, Genetic
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Predictive Value of Tests
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Risk Factors
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Tumor Suppressor Proteins*
Substances
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Carrier Proteins
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FABP7 protein, human
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Fatty Acid-Binding Protein 7
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Fatty Acid-Binding Proteins
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Fatty Acids
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Fatty Acids, Nonesterified
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Lipids
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Myelin P2 Protein
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Neoplasm Proteins
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Tumor Suppressor Proteins