[Lipoprotein lipase: a multifunctional enzyme in lipoprotein metabolism]

Presse Med. 1996 Feb 10;25(5):207-10.
[Article in French]

Abstract

Lipoprotein lipase (LPL) is a rate-limiting enzyme for the hydrolysis of triglycerides. Recently new insights into non-enzymatic functions have emerged. Complete lipoprotein lipase deficiency associated with chylomicronemia is an uncommon (1/10(6) in the general population) autosomal recessive disorder caused by many different lipoprotein lipase gene mutations and is characterized by high fasting plasma triglyceride levels, that can be complicated with acute pancreatitis. To date, about sixty gene mutations have been described throughout the world. Conversely to the homozygous state, the heterozygous state predisposes to a lipid profile that may be atherogenic evenly frequent (approximately 1/500) in the general population. These new clinical and biological insights reinforce the multifunctional role of lipoprotein lipase.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Acute Disease
  • Female
  • Genes / genetics*
  • Humans
  • Hyperlipoproteinemia Type I / complications*
  • Hyperlipoproteinemia Type I / diet therapy
  • Hyperlipoproteinemia Type I / metabolism
  • Lipoprotein Lipase / genetics*
  • Lipoprotein Lipase / metabolism
  • Lipoproteins / metabolism*
  • Male
  • Mutation
  • Pancreatitis / etiology*

Substances

  • Lipoproteins
  • Lipoprotein Lipase