mdm-2 oncoprotein expression associated with deletion of the long arm of chromosome 12 in a case of mantle cell lymphoma with blastoid transformation [corrected]

J H Haidar; R S Neiman; A Orazi; M Albitar; L J McCarthy; N Heerema

mdm-2 oncoprotein expression associated with deletion of the long arm of chromosome 12 in a case of mantle cell lymphoma with blastoid transformation [corrected]

Mod Pathol. 1996 Apr;9(4):355-9.

Authors

J H Haidar¹, R S Neiman, A Orazi, M Albitar, L J McCarthy, N Heerema

Affiliation

¹ Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, USA.

PMID: 8729971

Abstract

We report a unique case of mantle cell lymphoma in blastoid transformation associated with deletion of the long arm of chromosome 12 and with 90 kDa mdm-2 protein overexpression. Neither the mantle cells nor their blastoid counterparts expressed p53 gene product by immunohistochemical analysis. This seems to be the first reported case of this subtype of lymphoma associated with these specific cytogenetic and molecular genetic abnormalities.

Publication types

Case Reports

MeSH terms

Aged
Cell Transformation, Neoplastic / chemistry
Cell Transformation, Neoplastic / genetics
Cell Transformation, Neoplastic / pathology*
Chromosome Aberrations
Cyclin D1
Cyclins / biosynthesis
Humans
Lymphoma, Non-Hodgkin / chemistry
Lymphoma, Non-Hodgkin / genetics
Lymphoma, Non-Hodgkin / metabolism*
Male
Neoplasm Proteins / biosynthesis*
Nuclear Proteins*
Oncogene Proteins / biosynthesis
Proto-Oncogene Proteins / biosynthesis*
Proto-Oncogene Proteins c-mdm2
Tumor Suppressor Protein p53 / biosynthesis

Substances

Cyclins
Neoplasm Proteins
Nuclear Proteins
Oncogene Proteins
Proto-Oncogene Proteins
Tumor Suppressor Protein p53
Cyclin D1
MDM2 protein, human
Proto-Oncogene Proteins c-mdm2