Disseminated BCG infection in severe combined immunodeficiency presenting with severe anaemia and associated with gross hypersplenism after bone marrow transplantation

R Skinner; A L Appleton; M S Sprott; M R Barer; J G Magee; P J Darbyshire; M Abinun; A J Cant

Disseminated BCG infection in severe combined immunodeficiency presenting with severe anaemia and associated with gross hypersplenism after bone marrow transplantation

Bone Marrow Transplant. 1996 May;17(5):877-80.

Authors

R Skinner¹, A L Appleton, M S Sprott, M R Barer, J G Magee, P J Darbyshire, M Abinun, A J Cant

Affiliation

¹ Department of Paediatrics, Newcastle General Hospital, Newcastle-upon-Tyne, UK.

PMID: 8733714

Abstract

An infant with severe combined immunodeficiency (SCID) is described, who presented with severe anaemia and hepatosplenomegaly due to disseminated Bacillus Calmette-Guérin (BCG) infection involving the bone marrow, liver and spleen. After BMT, huge splenic enlargement occurred, presumably due to proliferation of engrafted donor lymphocytes, leading to severe hypersplenism. Peripheral blood cell consumption was resolved by splenectomy, but gradual loss of the marrow graft followed.

Publication types

Case Reports

MeSH terms

Anemia / blood
Anemia / etiology*
Anemia / therapy
BCG Vaccine / adverse effects
Blood Cell Count
Bone Marrow Transplantation / adverse effects*
Contraindications
Female
Graft Survival
Humans
Hypersplenism / etiology*
Hypersplenism / surgery
Infant
Mycobacterium bovis / pathogenicity*
Severe Combined Immunodeficiency / blood
Severe Combined Immunodeficiency / complications*
Severe Combined Immunodeficiency / therapy*
Splenectomy
Time Factors
Transplantation, Homologous
Tuberculosis / diagnosis
Tuberculosis / etiology*

Substances

BCG Vaccine