[Liver cirrhosis and granulomatous hepatitis after prolonged ingestion of lysine acetylsalicylate]

G D'Abrigeon; P Blanc; L Durand; D Larrey; H Michel

[Liver cirrhosis and granulomatous hepatitis after prolonged ingestion of lysine acetylsalicylate]

Gastroenterol Clin Biol. 1995 Nov;19(11):944-7.

[Article in French]

Authors

G D'Abrigeon¹, P Blanc, L Durand, D Larrey, H Michel

Affiliation

¹ Service d'Hépato-Gastroentérologie, Institut des Maladies de l'Appareil Digestif, Montpellier.

PMID: 8746055

Abstract

We report the case of a 75-year-old woman who was hospitalized for serum aminotransferase elevation. She had taken 1 g/d of salicylate therapy (Aspegic 1000) for 5 years, clorazepate for 10 years, naftidrofuryl for 8 months and quinapril for 3 months. Liver histology showed cirrhosis and granulomatous hepatitis. Discontinuation of salicylate therapy resulted in normalization of liver tests, although other drug administration was pursued. This observation suggests that salicylate therapy can induce cirrhosis.

Publication types

Case Reports

MeSH terms

Aged
Analgesics / adverse effects*
Analgesics / therapeutic use
Aspirin / adverse effects
Aspirin / analogs & derivatives*
Aspirin / therapeutic use
Chemical and Drug Induced Liver Injury / etiology*
Chemical and Drug Induced Liver Injury / pathology
Dose-Response Relationship, Drug
Female
Humans
Liver Cirrhosis / chemically induced*
Liver Cirrhosis / pathology
Lysine / adverse effects
Lysine / analogs & derivatives*
Lysine / therapeutic use
Rheumatic Diseases / drug therapy
Time Factors

Substances

Analgesics
Lysine
Aspirin
acetylsalicylic acid lysinate