Abstract
The possibility that the overall process of carcinogenesis may be linked to the deficiency of nitric oxide in a biological cell is examined. A hypothetical model of how this might operate to produce subtle changes in a cell resulting in and/or facilitating carcinogenesis is suggested.
MeSH terms
-
Animals
-
Cell Transformation, Neoplastic*
-
Enzyme Inhibitors / pharmacology
-
Humans
-
Isoenzymes / antagonists & inhibitors
-
Isoenzymes / metabolism
-
Models, Biological
-
Neoplasms / etiology
-
Neoplasms / pathology
-
Neoplasms / physiopathology*
-
Nitric Oxide / physiology*
-
Nitric Oxide Synthase / antagonists & inhibitors
-
Nitric Oxide Synthase / metabolism
-
Precancerous Conditions / physiopathology
Substances
-
Enzyme Inhibitors
-
Isoenzymes
-
Nitric Oxide
-
Nitric Oxide Synthase