The role of HMT (histamine N-methyltransferase) in airways: a review

S Okinaga; T Ohrui; H Nakazawa; K Yamauchi; E Sakurai; T Watanabe; K Sekizawa; H Sasaki

The role of HMT (histamine N-methyltransferase) in airways: a review

Methods Find Exp Clin Pharmacol. 1995 Nov:17 Suppl C:16-20.

Authors

S Okinaga¹, T Ohrui, H Nakazawa, K Yamauchi, E Sakurai, T Watanabe, K Sekizawa, H Sasaki

Affiliation

¹ Department of Geriatric Medicine, Tohoku University School of Medicine,Sendai City, Japan.

PMID: 8750789

Abstract

Histamine N-methyltransferase (HMT) expressed in the epithelial and endothelial cells of the airways is a principal enzyme degrading histamine in the body. This brief review summarizes the recent advances in molecular biology related to the pathophysiological role of HMT in regulating airway functions.

Publication types

Review

MeSH terms

Animals
Bronchi / enzymology*
Cloning, Molecular
Histamine / metabolism
Histamine N-Methyltransferase / genetics
Histamine N-Methyltransferase / physiology*
Humans
Respiratory Tract Infections / enzymology
Trachea / enzymology*
Virus Diseases / enzymology

Substances

Histamine
Histamine N-Methyltransferase