Abstract
The lineage of HIV-2-like viruses was studied in feral sooty mangabeys (SMs) by serological and genetic methods. Four feral sooty mangabeys were positive for simian immunodeficiency virus (SIV) antibodies and a new isolate, SIVsmSL92a, was obtained. Genetic analysis of gag genes showed that SIVsmSL92a was highly diverse and a distinct sequence subtype within the SIV sm/HIV-2 family. The results showed that SIVsm is the most diverse group of SIVs found thus far in a single monkey species.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Africa, Western
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Animals
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Base Sequence
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Blotting, Western
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Cercocebus atys / virology*
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Cloning, Molecular
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Cross Reactions
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Gene Products, gag / chemistry
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Gene Products, gag / genetics*
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Leukocytes, Mononuclear / virology
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Macaca mulatta / virology
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Molecular Sequence Data
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Phylogeny
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Polymerase Chain Reaction
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Sequence Alignment
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Sequence Analysis, DNA
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Serologic Tests
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Simian Immunodeficiency Virus / genetics*
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Simian Immunodeficiency Virus / isolation & purification*