A cross-sectional epidemiological study on "the relationship between five variables [Fish, Pig, Duck, Chicken and Integrated Fish Farming (IFF)] and influenza pandemic" was carried out in 697 disease surveillance spots in the rural areas of Shandong & Henan provides. Results suggested that ducks might have played an important role in the ecology of influenza. Pigs did not seem to be a greater culprit in ecology of influenza but gave the inconsistent view with the hypothesis that IFF could lead to human influenza pandemic.