Abstract
Four cases of primary central nervous system lymphomas treated with high dose cytosine arabinoside and high dose methotrexate prior to cranial irradiation are described. All patients achieved a complete clinical and radiological remission following treatment with chemotherapy alone. Three patients are alive with a follow-up period of 60, 45 og 24 months, respectively. One patient died 12 months after diagnosis at another hospital. Autopsy was not performed.
MeSH terms
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Adult
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Antimetabolites, Antineoplastic / administration & dosage*
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Antineoplastic Agents / administration & dosage*
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Brain Neoplasms / diagnostic imaging
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Brain Neoplasms / drug therapy*
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Brain Neoplasms / radiotherapy
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Combined Modality Therapy
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Cytarabine / administration & dosage*
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Female
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Follow-Up Studies
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Humans
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Lymphoma, Non-Hodgkin / diagnostic imaging
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Lymphoma, Non-Hodgkin / drug therapy*
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Lymphoma, Non-Hodgkin / radiotherapy
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Male
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Methotrexate / administration & dosage*
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Middle Aged
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Prognosis
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Tomography, X-Ray Computed
Substances
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Antimetabolites, Antineoplastic
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Antineoplastic Agents
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Cytarabine
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Methotrexate