Abstract
The occurrence of primary non Hodgkin's lymphoma of the liver has rarely been reported in patients with the human immunodeficiency virus infection. We report 3 cases in these patients, presenting with a single liver tumor in 2 cases and multiple tumors in one case. Diagnosis was made by guided-biopsy. Histologically, there was B diffuse large cell lymphoma in 2 cases, and immunoblastic lymphoma in one case. In one case, RNA of Epstein-Barr virus was found in the nucleus of tumor cells by in situ hybridization. No extrahepatic localization was found in any of the 3 cases. One patient died one week after diagnosis, but the 2 other patients were treated by chemotherapy and were still alive 6 and 30 months later. In patients infected by human immunodeficiency virus, primary non Hodgkin's lymphoma should be investigated in case of liver tumor in order to provide early treatment.
MeSH terms
-
AIDS-Related Opportunistic Infections / complications
-
AIDS-Related Opportunistic Infections / pathology
-
AIDS-Related Opportunistic Infections / virology
-
Acquired Immunodeficiency Syndrome / complications*
-
Adult
-
Fatal Outcome
-
Herpesviridae Infections / complications*
-
Herpesviridae Infections / pathology
-
Herpesviridae Infections / virology
-
Herpesvirus 4, Human / isolation & purification*
-
Humans
-
Liver Neoplasms / complications*
-
Liver Neoplasms / diagnostic imaging
-
Liver Neoplasms / pathology
-
Liver Neoplasms / virology
-
Lymphoma, Large B-Cell, Diffuse / complications*
-
Lymphoma, Large B-Cell, Diffuse / diagnostic imaging
-
Lymphoma, Large-Cell, Immunoblastic / complications*
-
Lymphoma, Large-Cell, Immunoblastic / pathology
-
Lymphoma, Large-Cell, Immunoblastic / virology
-
Male
-
Middle Aged
-
Tomography, X-Ray Computed
-
Tumor Virus Infections / complications*
-
Tumor Virus Infections / pathology
-
Tumor Virus Infections / virology