Squamous cell carcinoma primary of the stomach is an exceedingly rare neoplasm of unknown etiology. We report on a case of an antral tumour arising in the antrum of a 49-year-old woman. Histopathological study revealed a typical squamous cell carcinoma without evidence of glandular differentiation. Immuno-histochemical positivity for p53 suggests common etiopathogenic pathways with other histological types of gastric carcinoma.