Abstract
As a part of a research program directed to the discovery of novel antidepressant agents, a series of new hetero[2,1]benzothiazepine derivatives was synthesized. Some of these compounds antagonized the ptosis and motor depression induced by tetrabenazine and were also active in the Porsolt forced swimming test.
MeSH terms
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Animals
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Antidepressive Agents, Tricyclic / chemical synthesis*
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Antidepressive Agents, Tricyclic / pharmacology*
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Behavior, Animal / drug effects
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Benzazepines / chemical synthesis*
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Benzazepines / pharmacology*
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Body Temperature Regulation / drug effects
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Female
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Male
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Mice
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Motor Activity / drug effects
Substances
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Antidepressive Agents, Tricyclic
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Benzazepines