[Do calcium and zinc ions influence matrix molecule synthesis of chondrocytes?]

Z Orthop Ihre Grenzgeb. 1996 May-Jun;134(3):283-9. doi: 10.1055/s-2008-1039762.
[Article in German]

Abstract

The experiments described here tested the effect of various calcium (Ca) and Zinc (Zn) concentrations on cell proliferation and matrix molecule synthesis of fetal and adult bovine chondrocytes in monolayer cultures. Levels of Ca < 0.2 mM in a culture medium or the addition of Zn (0.1-50 microM) selectively promoted the production of collagen but did not affect significantly synthesis of proteoglycans. No change in proliferation of fetal and adult chondrocytes could be observed. In contrast 10 mM Ca promoted the hypertrophic differentiation of chondrocytes (e.g. expression of collagen type X). The results are related to calcium channel configurations in chondrocytes in the discussion.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Bone Matrix / metabolism*
  • Calcium / pharmacology*
  • Calcium Channels / metabolism
  • Cartilage / cytology*
  • Cartilage / drug effects
  • Cartilage / metabolism
  • Cattle
  • Cell Division / drug effects
  • Cells, Cultured
  • Collagen / biosynthesis
  • Fetus
  • Ions
  • Zinc / pharmacology*

Substances

  • Calcium Channels
  • Ions
  • Collagen
  • Zinc
  • Calcium