Abstract
Two amphotericin B resistant mutants of Ustilago maydis were isolated following direct selection from a wild-type population. Each mutant was demonstrated to be cross-resistant to nystatin yet remained sensitive to azoles. Sterol analysis indicated a sterol profile similar to the parent strain, precluding the involvement of an alteration in ergosterol biosynthesis as the cause of polyene resistance.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amphotericin B / pharmacology*
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Antifungal Agents / pharmacology*
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Drug Resistance, Microbial
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Fungicides, Industrial / pharmacology
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Microbial Sensitivity Tests
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Nystatin / pharmacology*
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Sterols / analysis
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Triazoles / pharmacology
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Ustilago / drug effects*
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Ustilago / genetics
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Ustilago / isolation & purification
Substances
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Antifungal Agents
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Fungicides, Industrial
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Sterols
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Triazoles
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Nystatin
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triadimefon
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Amphotericin B